منابع مشابه
Poxvirus orthologous clusters: toward defining the minimum essential poxvirus genome.
Increasingly complex bioinformatic analysis is necessitated by the plethora of sequence information currently available. A total of 21 poxvirus genomes have now been completely sequenced and annotated, and many more genomes will be available in the next few years. First, we describe the creation of a database of continuously corrected and updated genome sequences and an easy-to-use and extremel...
متن کاملPoxvirus DNA Replication
Poxviruses, of which vaccinia is the prototype, are complex DNA viruses that display an unusual degree of physical and genetic autonomy from the host cell. The vaccinia genome encodes most, if not all, of the functions required for three temporally regulated phases of transcription and for DNA replication (Moss 1990a,b, 1994; Traktman 1990a,b, 1991). In addition, the 192-kb genome encodes numer...
متن کاملPoxvirus DNA primase.
Poxviruses are large enveloped viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. At least six virus-encoded proteins are required for synthesis and processing of the double-stranded DNA genome of vaccinia virus, the prototype member of the family. One of these proteins, D5, is an NTPase that contains an N-terminal archaeoeukaryotic primase domain and a C-terminal supe...
متن کاملPoxvirus transcriptome analysis.
Expression of approximately two-thirds of the vaccinia virus (VACV) genome has been previously analyzed gene by gene, and the analysis has led to the classification of early-, intermediate-, and late-stage genes with distinct promoters and associated transcription factors. Assarsson et al. (1) reported the complete VACV transcriptome by using a tiling array. There are problems in application of...
متن کاملPoxvirus DNA replication.
Poxviruses are large, enveloped viruses that replicate in the cytoplasm and encode proteins for DNA replication and gene expression. Hairpin ends link the two strands of the linear, double-stranded DNA genome. Viral proteins involved in DNA synthesis include a 117-kDa polymerase, a helicase-primase, a uracil DNA glycosylase, a processivity factor, a single-stranded DNA-binding protein, a protei...
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ژورنال
عنوان ژورنال: Microbiological Reviews
سال: 1991
ISSN: 0146-0749
DOI: 10.1128/mmbr.55.1.80-122.1991